Design, synthesis and biological evaluation of trimethine cyanine dyes as fluorescent probes for the detection of tau fibrils in Alzheimer's disease brain and olfactory epithelium

ChemMedChem. 2013 Jun;8(6):891-7. doi: 10.1002/cmdc.201300090. Epub 2013 Apr 16.

Abstract

Shedding light on grey matter: Fluorescent trimethine cyanines were evaluated as imaging probes for neurofibrillary tangles in post-mortem brain sections of Alzheimer's disease patients. These probes bind to neurofibrillary tangles with high contrast and selectivity over amyloid β plaques.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / pathology
  • Animals
  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Brain / metabolism*
  • Brain / pathology
  • Carbocyanines / chemical synthesis
  • Carbocyanines / chemistry*
  • Carbocyanines / pharmacology
  • Cell Proliferation / drug effects
  • Dose-Response Relationship, Drug
  • Drug Design
  • Drug Screening Assays, Antitumor
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • Fluorescent Dyes / pharmacology
  • Hep G2 Cells
  • Humans
  • Male
  • Molecular Structure
  • Olfactory Mucosa / chemistry*
  • Olfactory Mucosa / metabolism
  • Olfactory Mucosa / pathology
  • Structure-Activity Relationship
  • Zebrafish / embryology
  • tau Proteins / analysis*

Substances

  • Antineoplastic Agents
  • Carbocyanines
  • Fluorescent Dyes
  • tau Proteins