A silicon photonic biosensor using phase-shifted Bragg gratings in slot waveguide

J Biophotonics. 2013 Oct;6(10):821-8. doi: 10.1002/jbio.201300012. Epub 2013 Apr 11.

Abstract

We present a novel silicon photonic biosensor using phase-shifted Bragg gratings in a slot waveguide. The optical field is concentrated inside the slot region, leading to efficient light-matter interaction. The Bragg gratings are formed with sidewall corrugations on the outside of the waveguide, and a phase shift is introduced to create a sharp resonant peak within the stop band. We experimentally demonstrate a high sensitivity of 340 nm/RIU measured in salt solutions and a high quality factor of 1.5 × 10⁴, enabling a low intrinsic limit of detection of 3 × 10⁻⁴ RIU. Furthermore, the silicon device was fabricated by a CMOS foundry, facilitating high-volume and low-cost production. Finally, we demonstrate the device's ability to interrogate specific biomolecular interactions, resulting in the first of its kind label-free biosensor.

Keywords: Bragg grating; biosensor; limit of detection; microfluidics; silicon photonics; slot waveguide.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biosensing Techniques / instrumentation
  • Biosensing Techniques / methods*
  • Dimethylpolysiloxanes
  • Microfluidic Analytical Techniques
  • Optical Phenomena
  • Photons*
  • Silicon*

Substances

  • Dimethylpolysiloxanes
  • baysilon
  • Silicon