Abstract
A method has been developed for the Pd-catalyzed synthesis of α-(hetero)aryl esters and amides through a Suzuki-Miyaura cross-coupling reaction. This method avoids the use of strong base, does not necessitate inert or low temperature formation of reagents, and does not require the use of a large excess of organometallic reagent. Utilization of organotrifluoroborate salts as nucleophilic partners allows a variety of functional groups and heterocyclic compounds to be tolerated.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Acetamides / chemistry*
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Boronic Acids / chemistry*
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Catalysis
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Chloroacetates / chemistry*
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Esters
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Heterocyclic Compounds / chemical synthesis*
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Heterocyclic Compounds / chemistry
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Indicators and Reagents / chemistry*
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Molecular Structure
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Palladium / chemistry*
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Salts / chemistry*
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Temperature
Substances
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Acetamides
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Boronic Acids
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Chloroacetates
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Esters
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Heterocyclic Compounds
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Indicators and Reagents
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Salts
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chloroacetamide
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Palladium