Altered cholesterol homeostasis in aged macrophages linked to neovascular macular degeneration

Jing Chen; Lois E H Smith

doi:10.1016/j.cmet.2013.03.010

Altered cholesterol homeostasis in aged macrophages linked to neovascular macular degeneration

Cell Metab. 2013 Apr 2;17(4):471-2. doi: 10.1016/j.cmet.2013.03.010.

Authors

Jing Chen¹, Lois E H Smith

Affiliation

¹ Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Abnormal lipid metabolism has been linked to age-related macular degeneration (AMD); choroidal neovascularization in late AMD commonly causes blindness. Sene et al. (2013) now demonstrate that in aged macrophages decreased ABCA1 expression, regulated by liver X receptor and miR-33, impairs export of intracellular cholesterol, which promotes neovascular AMD.

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