Adhesion molecules, endothelin-1 and lung function in seven population-based cohorts

Biomarkers. 2013 May;18(3):196-203. doi: 10.3109/1354750X.2012.762805. Epub 2013 Apr 5.

Abstract

Context: Endothelial function is abnormal in chronic obstructive pulmonary disease (COPD); whether endothelial dysfunction causes COPD is unknown.

Objective: Test associations of endothelial biomarkers with FEV1 using instrumental variables.

Methods: Among 26 907 participants with spirometry, ICAM-1, P-selectin, E-selectin and endothelin-1 were measured in subsets.

Results: ICAM-1 and P-selectin were inversely associated with FEV1 among European-Americans (-29 mL and -34 mL per standard deviation of log-transformed biomarker, p < 0.001), as was endothelin-1 among African-Americans (-22 mL, p = 0.008). Genetically-estimated ICAM-1 and P-selectin were not significantly associated with FEV1. The instrumental variable for endothelin-1 was non-informative.

Conclusion: Although ICAM-1, P-selectin and endothelin-1 were inversely associated with FEV1, associations for ICAM-1 and P-selectin do not appear causal.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biomarkers / metabolism
  • Black People
  • Black or African American
  • Cohort Studies
  • E-Selectin / genetics
  • E-Selectin / metabolism
  • Endothelin-1 / genetics
  • Endothelin-1 / metabolism
  • Endothelium, Vascular / metabolism*
  • Endothelium, Vascular / physiopathology
  • Female
  • Gene Expression*
  • Humans
  • Intercellular Adhesion Molecule-1 / genetics
  • Intercellular Adhesion Molecule-1 / metabolism
  • Lung / metabolism*
  • Lung / physiopathology
  • Male
  • Middle Aged
  • P-Selectin / genetics
  • P-Selectin / metabolism
  • Pulmonary Disease, Chronic Obstructive / ethnology
  • Pulmonary Disease, Chronic Obstructive / genetics*
  • Pulmonary Disease, Chronic Obstructive / physiopathology
  • Respiratory Function Tests
  • Spirometry
  • White People

Substances

  • Biomarkers
  • E-Selectin
  • Endothelin-1
  • P-Selectin
  • SELE protein, human
  • Intercellular Adhesion Molecule-1

Grants and funding