The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease

Protein Cell. 2013 Apr;4(4):248-50. doi: 10.1007/s13238-013-2841-3.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Coronavirus 3C Proteases
  • Cysteine Endopeptidases / metabolism
  • Humans
  • Isoxazoles / chemistry
  • Isoxazoles / pharmacology
  • Phenylalanine / analogs & derivatives
  • Protease Inhibitors / chemistry
  • Protease Inhibitors / metabolism
  • Protease Inhibitors / pharmacology
  • Protein Structure, Tertiary
  • Pyrrolidinones / chemistry
  • Pyrrolidinones / pharmacology
  • Rhinovirus / drug effects
  • Severe Acute Respiratory Syndrome / virology*
  • Severe acute respiratory syndrome-related coronavirus / drug effects
  • Severe acute respiratory syndrome-related coronavirus / enzymology*
  • Valine / analogs & derivatives
  • Viral Proteins / antagonists & inhibitors*
  • Viral Proteins / metabolism

Substances

  • Isoxazoles
  • Protease Inhibitors
  • Pyrrolidinones
  • Viral Proteins
  • Phenylalanine
  • Cysteine Endopeptidases
  • Coronavirus 3C Proteases
  • Valine
  • rupintrivir