Studies toward the biomimetic total synthesis of (-)-PF-1018

Org Lett. 2013 Apr 19;15(8):1866-9. doi: 10.1021/ol400508s. Epub 2013 Apr 2.

Abstract

Pericyclic reaction cascades are unparalleled in their ability to quickly generate complex structures with excellent stereocontrol. Herein, the use of a biomimetic Stille/8π electrocyclization/Diels-Alder cascade to successfully assemble the core structure of (-)-PF-1018 is reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography, X-Ray
  • Molecular Conformation
  • Molecular Structure
  • Pyrrolizidine Alkaloids / chemical synthesis*
  • Pyrrolizidine Alkaloids / chemistry
  • Stereoisomerism

Substances

  • Pyrrolizidine Alkaloids
  • PF 1018