Interaction of anticancer ruthenium compounds with proteins: high-resolution X-ray structures and raman microscopy studies of the adduct between hen egg white lysozyme and AziRu

Inorg Chem. 2013 Apr 15;52(8):4157-9. doi: 10.1021/ic4004142. Epub 2013 Mar 22.

Abstract

The binding properties of AziRu, a ruthenium(III) complex with high antiproliferative activity, toward a hen egg white lysozyme have been investigated by X-ray crystallography and Raman microscopy. The data provide clear evidence on the mechanism of AziRu-protein adduct formation and of ligand exchange in the crystal state.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / metabolism*
  • Chickens
  • Crystallography, X-Ray
  • Dimethyl Sulfoxide / analogs & derivatives*
  • Dimethyl Sulfoxide / chemistry
  • Dimethyl Sulfoxide / metabolism
  • Microscopy
  • Models, Molecular
  • Muramidase / chemistry
  • Muramidase / metabolism*
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / metabolism*
  • Protein Binding
  • Pyridines / chemistry
  • Pyridines / metabolism
  • Ruthenium / chemistry
  • Ruthenium / metabolism*
  • Ruthenium Compounds

Substances

  • Antineoplastic Agents
  • Organometallic Compounds
  • Pyridines
  • Ruthenium Compounds
  • imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III)
  • Ruthenium
  • hen egg lysozyme
  • Muramidase
  • Dimethyl Sulfoxide