Effects of Taishan Robinia pseudoacacia Polysaccharides on immune function in chickens

Int Immunopharmacol. 2013 Apr;15(4):661-5. doi: 10.1016/j.intimp.2013.02.026. Epub 2013 Mar 15.

Abstract

To determine the immune function of Taishan Robinia pseudoacacia Polysaccharide (TRPPS) on chickens, 240 chickens were selected as experimental animals and treated with various doses of TRPPS by hypodermic injection before immunized NDV inactivated vaccine. The results indicated that any dose of TRPPS could significantly promote the development of the immune organs, increase the quantity of leukocyte and the ratio of lymphocyte, and improve the antibody titers against Newcastle disease. Meanwhile, it also increased the magnitude of SIgA in duodenum. However, the dose of 200 mg/ml showed to be the most effective. Therefore, in terms of improving immunologic function and production performance, TRPPS could be used as a vaccine immunopotentiator for immune responses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / administration & dosage
  • Adjuvants, Immunologic / isolation & purification
  • Adjuvants, Immunologic / therapeutic use*
  • Animals
  • Antibodies, Viral / blood
  • Chickens / immunology*
  • Disease Models, Animal
  • Duodenum / drug effects
  • Duodenum / immunology
  • Immunity, Humoral / drug effects
  • Immunity, Mucosal / drug effects
  • Immunoglobulin A, Secretory / immunology
  • Leukocyte Count
  • Newcastle Disease / immunology
  • Newcastle Disease / prevention & control*
  • Newcastle disease virus / immunology
  • Polysaccharides / administration & dosage
  • Polysaccharides / isolation & purification
  • Polysaccharides / therapeutic use*
  • Poultry Diseases / immunology
  • Poultry Diseases / prevention & control*
  • Robinia / chemistry*
  • Vaccines, Inactivated
  • Viral Vaccines / immunology

Substances

  • Adjuvants, Immunologic
  • Antibodies, Viral
  • Immunoglobulin A, Secretory
  • Polysaccharides
  • Vaccines, Inactivated
  • Viral Vaccines