Dynamic bone imaging with 99mTc-labeled diphosphonates and 18F-NaF: mechanisms and applications

J Nucl Med. 2013 Apr;54(4):590-9. doi: 10.2967/jnumed.112.114298. Epub 2013 Mar 12.

Abstract

Dynamic bone scanning with (99m)Tc-labeled diphosphonates and (18)F-labeled sodium fluoride provides functional information sensitive for subtle changes in bone turnover and perfusion, which assists the clinical management of numerous osseous pathologies. This article reviews the mechanisms of uptake of (99m)Tc-labeled diphosphonates and (18)F-sodium fluoride and discusses and compares the performance of these bone-seeking radiotracers for clinical and research applications, using dynamic and multiple-time-point imaging protocols and quantitative techniques.

Publication types

  • Review

MeSH terms

  • Biological Transport
  • Bone and Bones / diagnostic imaging*
  • Bone and Bones / metabolism
  • Fluorine Radioisotopes*
  • Humans
  • Multimodal Imaging / methods*
  • Positron-Emission Tomography*
  • Sodium Fluoride* / metabolism
  • Technetium Tc 99m Medronate* / metabolism
  • Tomography, X-Ray Computed*

Substances

  • Fluorine Radioisotopes
  • Sodium Fluoride
  • Technetium Tc 99m Medronate