Lipophilic components from Fructus Viticis Negundo and their anti-tumor activities

Danning Huang; Shan Qing; Guangyao Zeng; Yajing Wang; Hong Guo; Jianbing Tan; Yingjun Zhou

doi:10.1016/j.fitote.2013.02.009

Lipophilic components from Fructus Viticis Negundo and their anti-tumor activities

Fitoterapia. 2013 Apr:86:144-8. doi: 10.1016/j.fitote.2013.02.009. Epub 2013 Feb 27.

Authors

Danning Huang¹, Shan Qing, Guangyao Zeng, Yajing Wang, Hong Guo, Jianbing Tan, Yingjun Zhou

Affiliation

¹ School of Pharmaceutical Sciences, Central South University, Changsha 410000, China.

PMID: 23454672
DOI: 10.1016/j.fitote.2013.02.009

Abstract

Two new triterpenoids, (24R/S)-24-hydroxy-3α 10α-epoxy-9-eip-cucurbita-25-ene (1a, b), as well as six known compounds (3-8), were isolated from the extraction of Fructus Viticis Negundo. Their structures were established on the basis of spectral analysis. In addition, all the compounds were tested for inhibitory effect against K-562 and A-549 cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / pharmacology
Antineoplastic Agents, Phytogenic / therapeutic use*
Drugs, Chinese Herbal / chemistry
Drugs, Chinese Herbal / pharmacology
Drugs, Chinese Herbal / therapeutic use*
Fruit
Humans
Hydrophobic and Hydrophilic Interactions
K562 Cells
Neoplasms / drug therapy*
Phytotherapy*
Triterpenes / chemistry
Triterpenes / isolation & purification
Triterpenes / pharmacology
Triterpenes / therapeutic use*
Vitex / chemistry*

Substances

24-hydroxy-3alpha,10alpha-epoxy-9-eip-cucurbita-25-ene
Antineoplastic Agents, Phytogenic
Drugs, Chinese Herbal
Triterpenes