Recent advances in microchip electrophoresis for amino acid analysis

Anal Bioanal Chem. 2013 Oct;405(25):7907-18. doi: 10.1007/s00216-013-6830-4. Epub 2013 Feb 24.

Abstract

With the maturation of microfluidic technologies, microchip electrophoresis has been widely employed for amino acid analysis owing to its advantages of low sample consumption, reduced analysis time, high throughput, and potential for integration and automation. In this article, we review the recent progress in amino acid analysis using microchip electrophoresis during the period from 2007 to 2012. Innovations in microchip materials, surface modification, sample introduction, microchip electrophoresis, and detection methods are documented, as well as nascent applications of amino acid analysis in single-cell analysis, microdialysis sampling, food analysis, and extraterrestrial exploration. Without doubt, more applications of microchip electrophoresis in amino acid analysis may be expected soon.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acids / analysis*
  • Animals
  • Electrophoresis, Microchip / instrumentation*
  • Electrophoresis, Microchip / methods*
  • Equipment Design
  • Food Analysis / instrumentation
  • Food Analysis / methods
  • Humans
  • Microdialysis / instrumentation
  • Microdialysis / methods
  • Single-Cell Analysis / instrumentation
  • Single-Cell Analysis / methods

Substances

  • Amino Acids