Abstract
We investigated the prevalence of plasmid-mediated quinolone resistance genes in 756 clinical isolates of Enterobacteriaceae originating from Microbiology Diagnostic Laboratories of North-East Italy. Five point zero two percent of isolates carried a qnr determinant while the aac(6')-Ib-cr determinant was detected in 9·25% of isolates. We also investigated the association between the plasmid-mediated quinolone resistance and the beta-lactamase genes, and characterized the plasmids carrying these determinants of resistance.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Drug Resistance, Bacterial
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Enterobacteriaceae / drug effects
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Enterobacteriaceae / enzymology
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Enterobacteriaceae / genetics*
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Enterobacteriaceae / isolation & purification
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Enterobacteriaceae Infections / drug therapy
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Enterobacteriaceae Infections / microbiology
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Escherichia coli Proteins / genetics
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Fluoroquinolones / pharmacology*
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Humans
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Italy
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Microbial Sensitivity Tests
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Plasmids / genetics*
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Prevalence
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beta-Lactamases / genetics
Substances
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Anti-Bacterial Agents
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Escherichia coli Proteins
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Fluoroquinolones
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Qnr protein, E coli
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beta-Lactamases