Abstract
An efficient Ru-catalyzed synthesis of dihydrofuroquinolines from azido-cyclopropyl ketones via the reduction-cyclization-rearrangement process is reported. A plausible reaction mechanism for this process is depicted. Additionally, when the reaction was carried out under H2 (1 atm) in the presence of Pd/C, 4-quinolones were obtained in excellent yields.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Combinatorial Chemistry Techniques
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Cyclization
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Cyclopropanes / chemistry*
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Furans / chemical synthesis*
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Furans / chemistry
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Heterocyclic Compounds, 3-Ring / chemical synthesis*
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Heterocyclic Compounds, 3-Ring / chemistry
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Ketones / chemistry*
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Molecular Structure
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Quinolines / chemical synthesis*
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Quinolines / chemistry
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Ruthenium / chemistry*
Substances
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Cyclopropanes
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Furans
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Heterocyclic Compounds, 3-Ring
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Ketones
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Quinolines
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Ruthenium