Hospital readmissions are quality indicators of healthcare delivery. Our purpose is to examine the effect of a program designed to reduce readmissions after total joint replacement. We initiated a comprehensive program with 4 goals: (1) outpatient workup of venous thromboembolism; (2) decrease surgical site infection; (3) early follow-up with primary care physicians; and (4) increase physician awareness of the financial and quality-related ramifications of unplanned readmissions. We then compared readmission rates before our initiative was instituted (2005-2006) to 3 years after implementation (2007-2009). Readmission rates preintervention were 3.70 and 3.29 for total hip replacement (THR) and knee replacement (TKR), respectively. Postintervention rates fell to 1.78 and 1.98, respectively, representing a 47.2% reduction of readmission for THR and 39.8% for TKR (P<.05). These results demonstrate the success of our program in reducing readmissions. This may result in reductions in healthcare costs and improvement in quality of care.