Pd(II)-catalyzed di-o-olefination of carbazoles directed by the protecting N-(2-pyridyl)sulfonyl group

Org Lett. 2013 Mar 1;15(5):1120-3. doi: 10.1021/ol400206k. Epub 2013 Feb 18.

Abstract

Despite the significance of carbazole in pharmacy and material science, examples of the direct C-H functionalization of this privileged unit are quite rare. The N-(2-pyridyl)sulfonyl group enables the Pd(II)-catalyzed ortho-olefination of carbazoles and related systems, acting as both a directing and readily removable protecting group. This method features ample structural versatility, affording typically the double ortho-olefination products (at C1 and C8) in satisfactory yields and complete regiocontrol. The application of this procedure to related heterocyclic systems, such as indoline, is also described.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkenes / chemistry*
  • Carbazoles / chemical synthesis
  • Carbazoles / chemistry*
  • Catalysis
  • Molecular Structure
  • Palladium / chemistry*
  • Pyridines / chemistry
  • Sulfones / chemistry

Substances

  • Alkenes
  • Carbazoles
  • Pyridines
  • Sulfones
  • Palladium