Abstract
Two novel phenethylamine alkaloids were isolated from Streptomyces sp. YIM 10049. On the basis of spectral data, their structures were determined as (S)-N-(cu-phenylethyl)-2 -hydroxyl-acrylimine (1) and (S)-N-nitroso-1-amino-p-hydroxy phenylethanol (2). Three known compounds, indole-3-carboxylic acid (3), cyclo(L-Ala-L-Tyr)(4), and bis(2-ethylhexyl) phthalate (5), were also isolated and characterized. Compound 1 is a rare enol tautomer, and compound 2 an unusual phenethylamine alkaloid with a N-NO group.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry*
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Alkaloids / isolation & purification
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Alkaloids / pharmacology
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Antibiotics, Antineoplastic / chemistry
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Antibiotics, Antineoplastic / pharmacology
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Antifungal Agents / pharmacology
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Cell Line, Tumor
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Chromatography, Thin Layer
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Ethylamines / chemistry*
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Ethylamines / isolation & purification
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Ethylamines / pharmacology
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Fermentation
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Fusarium / drug effects
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Humans
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Microbial Sensitivity Tests
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Phenethylamines / chemistry*
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Phenethylamines / isolation & purification
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Streptomyces / chemistry*
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Streptomyces / growth & development
Substances
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(S)-N-nitroso-1-amino-p-hydroxy phenylethanol
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Alkaloids
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Antibiotics, Antineoplastic
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Antifungal Agents
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Ethylamines
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Phenethylamines