Abstract
The Cu(II) complexes of cyclen and two of its heterosubstituted analogues were shown to be efficient oxidative DNA cleavers. The reactivity strongly depends on the heteroatom inserted into the macrocycle (O > S > N).
MeSH terms
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Coordination Complexes / chemistry*
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Copper / chemistry*
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Crystallography, X-Ray
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Cyclams
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DNA / chemistry*
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DNA / metabolism
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DNA Cleavage
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Heterocyclic Compounds / chemistry*
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Molecular Conformation
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Oxidation-Reduction
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Plasmids / chemistry
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Plasmids / metabolism
Substances
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Coordination Complexes
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Cyclams
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Heterocyclic Compounds
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Copper
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DNA
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cyclen