The CAGE questionnaire, integrated with socio-demographic data, was submitted to 239 workers of two construction companies. The statistical analysis was performed using SPSS 17.0. The association between alcohol abuse and other variables was performed by using the Chi-Square test and the possible correlation by using the coefficient r of Spearman. Alcohol abuse has affected the 21.3% of workers, with prevalence of mechanical fitters (80.00%), scaffolders (60.00%) and drivers (50.00%) and workers aged 31-40 years (28.33%) and > 60 years (30.00%). Alcohol abuse was associated with nationality (p = 0.001) (prevalence of 44.0% among subjects of European non-Italian nationality), marital status (p < 0.001) (prevalence of 55.55% among separated subjects) and education (p < 0.05) (prevalence of 28.18% among subjects with middle school diploma). The results suggest the need for preventive strategies and management of alcohol abuse, including for the possible interaction between alcohol and solvents, used in construction industry, in determining the "chronic solvent encefhalopathy" (CSE).