Lipid metabolism greases the stem cell engine

Clifford D L Folmes; Sungjo Park; Andre Terzic

doi:10.1016/j.cmet.2013.01.010

Lipid metabolism greases the stem cell engine

Cell Metab. 2013 Feb 5;17(2):153-5. doi: 10.1016/j.cmet.2013.01.010.

Authors

Clifford D L Folmes¹, Sungjo Park, Andre Terzic

Affiliation

¹ Center for Regenerative Medicine, Mayo Clinic, Rochester, MN 55901, USA.

PMID: 23395162
DOI: 10.1016/j.cmet.2013.01.010

Abstract

Metabolic plasticity is increasingly postulated to be vital in the transition between stemness maintenance and lineage specification. Knobloch et al. (2012) now demonstrate that regulation of lipogenesis by fatty acid synthase and Spot14-dependent malonyl-CoA supply determines the proliferative activity of resident neural stem cells, contributing to adult neurogenesis.

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