Hand-holding for retrohoming in a molecular diversity dance

Structure. 2013 Feb 5;21(2):195-6. doi: 10.1016/j.str.2013.01.008.

Abstract

In bacterial systems, adaptive protein sequence changes can be mediated by diversity-generating retroelements in a process known as retrohoming. An accessory variability determinant (Avd), together with a reverse transcriptase (RT), is critically involved in this process. In this issue of Structure, Alayyoubi and colleagues describe the structure of Avd as a basis for interactions with RT that promote retrohoming.

Publication types

  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Bacteriophages / enzymology*
  • Bordetella / virology*
  • RNA-Directed DNA Polymerase / chemistry*
  • Retroelements*
  • Viral Proteins / chemistry*

Substances

  • Retroelements
  • Viral Proteins
  • RNA-Directed DNA Polymerase