XtalFluor-E, an efficient coupling reagent for amidation of carboxylic acids

Org Lett. 2013 Feb 15;15(4):902-5. doi: 10.1021/ol400045d. Epub 2013 Feb 5.

Abstract

Amides were produced from carboxylic acids and amines by using XtalFluor-E as an activator. Even poorly reactive carboxylic acids can be transformed to amides. In addition, optically active amines and/or carboxylic acids were not epimerized/racemized during the process.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemical synthesis*
  • Amides / chemistry
  • Amines / chemistry*
  • Carboxylic Acids / chemistry*
  • Catalysis
  • Combinatorial Chemistry Techniques
  • Hydrocarbons, Fluorinated / chemistry*
  • Indicators and Reagents
  • Molecular Structure
  • Sulfur Compounds / chemistry*

Substances

  • Amides
  • Amines
  • Carboxylic Acids
  • Hydrocarbons, Fluorinated
  • Indicators and Reagents
  • Sulfur Compounds
  • diethylaminodifluorosulfinium tetrafluoroborate