In this paper, the complete mitochondrial genome of Luciogobius platycephalus was first determined. The genome is 16,478 bp in length and consists of 13 protein-coding genes, 22 tRNA genes, 2 ribosomal RNA genes, and 2 main non-coding regions (the control region and the origin of the light-strand replication). The overall base composition of L. platycephalus is 29.1% for T, 26.7% for C, 29.2% for A, and 15.1% for G, with a slight A+T bias of 58.3%. It has the typical vertebrate mitochondrial gene arrangement.