Skull thickness and density measures of normal pediatric crania would inform multiple disciplines including neurosurgery, optical and magnetoelectrophysiological imaging, and biomechanical modeling of head trauma. We report on a new method for automated extraction of in vivo skull thickness and density measures of pediatric crania based on x-ray computed tomography scans (CT). Data were obtained from a clinical image repository for pediatric populations in whom no pathology was noted. Skull thickness and density measures were systematically obtained across the calvarium. We find a set of measures that correlated with physiological age that are likely to prove useful in multiple disciplines.