Hydrodynamically driven self-assembly of giant vesicles of metal nanoparticles for remote-controlled release

Jie He; Zengjiang Wei; Lei Wang; Zuleykhan Tomova; Taarika Babu; Chaoyang Wang; Xiaojun Han; John T Fourkas; Zhihong Nie

doi:10.1002/anie.201208425

Hydrodynamically driven self-assembly of giant vesicles of metal nanoparticles for remote-controlled release

Angew Chem Int Ed Engl. 2013 Feb 25;52(9):2463-8. doi: 10.1002/anie.201208425. Epub 2013 Jan 30.

Authors

Jie He¹, Zengjiang Wei, Lei Wang, Zuleykhan Tomova, Taarika Babu, Chaoyang Wang, Xiaojun Han, John T Fourkas, Zhihong Nie

Affiliation

¹ Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.

PMID: 23362104
DOI: 10.1002/anie.201208425

Abstract

The hydrodynamics of laminar flow in a microfluidic device has been used to control the continuous self-assembly of gold nanoparticles (NPs) tethered with amphiphilic block copolymers. Spherical micelles, giant vesicles (500 nm-2.0 μm), or disk-like micelles could be formed by varying the flow rates of fluids. Such vesicles can release encapsulated hydrophilic species by using near-IR light.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Delayed-Action Preparations / chemistry*
Hydrophobic and Hydrophilic Interactions
Metal Nanoparticles / chemistry*
Micelles
Microfluidic Analytical Techniques / instrumentation
Microfluidic Analytical Techniques / methods
Polymers / chemistry*

Substances

Delayed-Action Preparations
Micelles
Polymers