Asperterpenoid A, a new sesterterpenoid as an inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B from the culture of Aspergillus sp. 16-5c

Xishan Huang; Hongbo Huang; Hanxiang Li; Xuefeng Sun; Huarong Huang; Yongjun Lu; Yongcheng Lin; Yuhua Long; Zhigang She

doi:10.1021/ol303549c

Asperterpenoid A, a new sesterterpenoid as an inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B from the culture of Aspergillus sp. 16-5c

Org Lett. 2013 Feb 15;15(4):721-3. doi: 10.1021/ol303549c. Epub 2013 Jan 29.

Authors

Xishan Huang¹, Hongbo Huang, Hanxiang Li, Xuefeng Sun, Huarong Huang, Yongjun Lu, Yongcheng Lin, Yuhua Long, Zhigang She

Affiliation

¹ School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.

PMID: 23360543
DOI: 10.1021/ol303549c

Abstract

Asperterpenoid A (1), a novel sesterterpenoid with a new carbon skeleton, has been isolated from a mangrove endophytic fungus Aspergillus sp. 16-5c. Its structure was characterized by extensive spectroscopic methods, and the absolute configuration was determined by single crystal X-ray diffraction analysis. Asperterpenoid A (1) exhibited strong inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB) with an IC(50) value of 2.2 μM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aspergillus / chemistry*
Crystallography, X-Ray
Inhibitory Concentration 50
Molecular Conformation
Molecular Structure
Mycobacterium tuberculosis / drug effects*
Mycobacterium tuberculosis / metabolism
Protein Tyrosine Phosphatase, Non-Receptor Type 1 / antagonists & inhibitors*
Sesquiterpenes
Sesterterpenes / chemistry
Sesterterpenes / isolation & purification*
Sesterterpenes / pharmacology*

Substances

Sesquiterpenes
Sesterterpenes
asperterpenoid A
Protein Tyrosine Phosphatase, Non-Receptor Type 1