Microarray analysis of neonatal brain exposed to cadmium during gestation and lactation

J Toxicol Sci. 2013 Feb;38(1):151-3. doi: 10.2131/jts.38.151.

Abstract

DNA microarray containing 30,000 genes was used to monitor the transcriptional response of the neonatal brain after cadmium (Cd) exposure. C57BL/6J pregnant mice were exposed to Cd (10 ppm) during gestation and lactation via drinking water. In a comparison between the Cd-exposed neonatal brain and control, three genes including transferrin receptor (Tfrc) were up-regulated and one gene was down-regulated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Brain / drug effects*
  • Brain / metabolism
  • Cadmium / toxicity*
  • Environmental Pollutants / toxicity*
  • Female
  • Gene Expression Profiling
  • Gene Expression Regulation / drug effects*
  • Integrin beta4 / genetics
  • Lactation
  • Maternal-Fetal Exchange
  • Membrane Proteins / genetics
  • Mice
  • Mice, Inbred C57BL
  • Nerve Tissue Proteins / genetics
  • Oligonucleotide Array Sequence Analysis
  • Pregnancy
  • Real-Time Polymerase Chain Reaction
  • Receptors, Transferrin / genetics
  • Selenoproteins / genetics
  • Semaphorins

Substances

  • Environmental Pollutants
  • Integrin beta4
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Receptors, Transferrin
  • Selenof protein, mouse
  • Selenoproteins
  • Sema5A protein, mouse
  • Semaphorins
  • Tfrc protein, mouse
  • Cadmium