Antifungal activity of volatile organic compounds from Streptomyces alboflavus TD-1

FEMS Microbiol Lett. 2013 Apr;341(1):45-51. doi: 10.1111/1574-6968.12088. Epub 2013 Feb 11.

Abstract

Streptomyces sp. TD-1 was identified as Streptomyces alboflavus based on its morphological characteristics, physiological properties, and 16S rDNA gene sequence analysis. The antifungal activity of the volatile-producing S. alboflavus TD-1 was investigated. Results showed that volatiles generated by S. alboflavus TD-1 inhibited storage fungi Fusarium moniliforme Sheldon, Aspergillus flavus, Aspergillus ochraceus, Aspergillus niger, and Penicillum citrinum in vitro. GC/MS analysis revealed that 27 kinds of volatile organic compounds were identified from the volatiles of S. alboflavus TD-1 mycelia, among which the most abundant compound was 2-methylisoborneol. Dimethyl disulfide was proved to have antifungal activity against F. moniliforme by fumigation in vitro.

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology*
  • Aspergillus niger / drug effects
  • Aspergillus niger / growth & development
  • Camphanes / chemistry
  • Camphanes / isolation & purification
  • Disulfides / chemistry
  • Disulfides / isolation & purification
  • Disulfides / pharmacology
  • Fusarium / drug effects
  • Fusarium / growth & development
  • Gas Chromatography-Mass Spectrometry
  • Genes, Fungal
  • Microbial Sensitivity Tests
  • Mycelium / chemistry
  • Penicillium / drug effects
  • Penicillium / growth & development
  • Phylogeny
  • RNA, Fungal / analysis
  • RNA, Ribosomal, 16S / analysis
  • Spores, Fungal / drug effects
  • Spores, Fungal / growth & development
  • Streptomyces / chemistry*
  • Streptomyces / classification
  • Streptomyces / genetics
  • Volatile Organic Compounds / chemistry
  • Volatile Organic Compounds / isolation & purification*
  • Volatile Organic Compounds / pharmacology*

Substances

  • Antifungal Agents
  • Camphanes
  • Disulfides
  • RNA, Fungal
  • RNA, Ribosomal, 16S
  • Volatile Organic Compounds
  • 2-methylisoborneol
  • dimethyl disulfide