Activation of the mTOR signaling pathway by L-leucine in 5q- syndrome and other RPS14-deficient erythroblasts

Leukemia. 2013 Aug;27(8):1760-3. doi: 10.1038/leu.2013.20. Epub 2013 Jan 22.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anemia, Macrocytic / genetics*
  • Anemia, Macrocytic / metabolism*
  • Chromosome Deletion
  • Chromosomes, Human, Pair 5 / genetics
  • Chromosomes, Human, Pair 5 / metabolism
  • Enzyme Activation / drug effects
  • Erythroblasts / metabolism*
  • Humans
  • Leucine / pharmacology*
  • Ribosomal Proteins / deficiency*
  • Ribosomal Proteins / genetics
  • Signal Transduction / drug effects*
  • TOR Serine-Threonine Kinases / metabolism*

Substances

  • RPS14 protein, human
  • Ribosomal Proteins
  • TOR Serine-Threonine Kinases
  • Leucine

Supplementary concepts

  • Chromosome 5q Deletion Syndrome