Severe methotrexate toxicity due to a concomitant administration of ciprofloxacin

Med Mal Infect. 2013 Jan;43(1):39-41. doi: 10.1016/j.medmal.2012.11.006. Epub 2013 Jan 14.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Anti-Bacterial Agents / adverse effects*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / therapeutic use
  • Antifungal Agents / therapeutic use
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Antiviral Agents / therapeutic use
  • Bicarbonates / adverse effects
  • Bicarbonates / therapeutic use
  • Bleomycin / administration & dosage
  • Ciprofloxacin / adverse effects*
  • Ciprofloxacin / chemistry
  • Ciprofloxacin / therapeutic use
  • Crystallization
  • Cyclophosphamide / administration & dosage
  • Cytarabine / administration & dosage
  • Diarrhea / chemically induced
  • Doxorubicin / administration & dosage
  • Drug Eruptions / etiology*
  • Drug Interactions
  • Etoposide / administration & dosage
  • Female
  • Fluid Therapy
  • Fungemia / complications
  • Fungemia / drug therapy
  • Humans
  • Hydrogen-Ion Concentration
  • Ifosfamide / administration & dosage
  • Lymphoma, B-Cell / drug therapy
  • Mediastinal Neoplasms / drug therapy
  • Metabolic Clearance Rate / drug effects
  • Methotrexate / administration & dosage
  • Methotrexate / adverse effects*
  • Methotrexate / blood
  • Methotrexate / pharmacokinetics
  • Mucositis / chemically induced*
  • Pancytopenia / chemically induced*
  • Prednisone / administration & dosage
  • Solubility
  • Urine / chemistry
  • Vindesine / administration & dosage

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Antiviral Agents
  • Bicarbonates
  • Cytarabine
  • Bleomycin
  • Ciprofloxacin
  • Etoposide
  • Doxorubicin
  • Cyclophosphamide
  • Vindesine
  • Ifosfamide
  • Prednisone
  • Methotrexate

Supplementary concepts

  • IVAM regimen
  • LNH 87 protocol