Redirection of T cells with a first fully humanized bispecific CD33-CD3 antibody efficiently eliminates AML blasts without harming hematopoietic stem cells

Leukemia. 2013 Apr;27(4):964-7. doi: 10.1038/leu.2013.18. Epub 2013 Jan 17.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Bispecific / immunology*
  • Antibodies, Monoclonal, Humanized / immunology*
  • CD3 Complex / immunology*
  • Flow Cytometry
  • Hematopoietic Stem Cells / immunology*
  • Humans
  • Leukemia, Myeloid, Acute / immunology
  • Leukemia, Myeloid, Acute / therapy*
  • Sialic Acid Binding Ig-like Lectin 3 / immunology*
  • T-Lymphocytes / immunology*

Substances

  • Antibodies, Bispecific
  • Antibodies, Monoclonal, Humanized
  • CD3 Complex
  • Sialic Acid Binding Ig-like Lectin 3