Myriberine A, a new alkaloid with an unprecedented heteropentacyclic skeleton from Myrioneuron faberi

Org Lett. 2013 Feb 1;15(3):590-3. doi: 10.1021/ol3034065. Epub 2013 Jan 15.

Abstract

Myriberine A (1) possessing an unprecedented carbon skeleton was isolated from Myrioneuron faberi. The structure and absolute configuration of 1 were elucidated by a combination of spectroscopic data, X-ray crystallographic, and computational methods. Myriberine A (1) demonstrated inhibition against the hepatitis C virus (HCV) life cycle in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Antiviral Agents / chemistry*
  • Antiviral Agents / isolation & purification*
  • Antiviral Agents / pharmacology
  • Crystallography, X-Ray
  • Drugs, Chinese Herbal / chemistry*
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • HL-60 Cells
  • Hepacivirus / drug effects
  • Heterocyclic Compounds, 4 or More Rings / chemistry*
  • Heterocyclic Compounds, 4 or More Rings / isolation & purification*
  • Heterocyclic Compounds, 4 or More Rings / pharmacology
  • Humans
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Rubiaceae / chemistry*

Substances

  • Alkaloids
  • Antiviral Agents
  • Drugs, Chinese Herbal
  • Heterocyclic Compounds, 4 or More Rings
  • myriberine A