Fatty acid control of growth of human cervical and endometrial cancer cells

R P Gleeson; M Ayub; J T Wright; C B Wood; N A Habib; W P Soutter; M H Sullivan; J O White

doi:10.1038/bjc.1990.113

Fatty acid control of growth of human cervical and endometrial cancer cells

Br J Cancer. 1990 Apr;61(4):500-3. doi: 10.1038/bjc.1990.113.

Authors

R P Gleeson¹, M Ayub, J T Wright, C B Wood, N A Habib, W P Soutter, M H Sullivan, J O White

Affiliation

¹ Institute of Obstetrics and Gynaecology, Hammersmith Hospital, London, UK.

Abstract

Stearic acid and iodo-stearic and inhibited cell growth in a cervical cancer cell line (HOG-1) in a dose-related manner, with a half maximal effect at 50 microM stearic acid. Addition of oleic acid abrogated the effect of stearic acid. EGF-stimulated DNA synthesis and growth of HOG-1 cells was inhibited in the presence of stearic acid without any apparent effect on EGF receptor number or affinity.

MeSH terms

Cell Division / drug effects
Epidermal Growth Factor / pharmacology
Female
Humans
Stearic Acids / therapeutic use*
Tumor Cells, Cultured / drug effects
Tumor Cells, Cultured / pathology
Uterine Cervical Neoplasms / drug therapy
Uterine Cervical Neoplasms / pathology*
Uterine Neoplasms / drug therapy
Uterine Neoplasms / pathology*

Substances

Stearic Acids
Epidermal Growth Factor