Memoirs of a reincarnated T cell

Cell Stem Cell. 2013 Jan 3;12(1):6-8. doi: 10.1016/j.stem.2012.12.009.

Abstract

In two studies published in this issue of Cell Stem Cell,Nishimura et al. (2013) and Vizcardo et al. (2013) reprogram mature, antigen-specific cytotoxic T cells into induced pluripotent stem cells (iPSCs). The antigen-specific iPSCs can be redifferentiated into "rejuvenated" proliferative T cells and have broad applications for adoptive immunotherapy.

Publication types

  • Comment

MeSH terms

  • Cell Culture Techniques / methods*
  • Cell Differentiation / physiology*
  • Humans
  • Induced Pluripotent Stem Cells / cytology*
  • Induced Pluripotent Stem Cells / metabolism*
  • MART-1 Antigen / metabolism*
  • T-Lymphocytes / cytology*
  • T-Lymphocytes, Cytotoxic / cytology*
  • T-Lymphocytes, Cytotoxic / metabolism*

Substances

  • MART-1 Antigen