Lanostane triterpenes from cultures of the Basidiomycete Ganoderma orbiforme BCC 22324

Masahiko Isaka; Panida Chinthanom; Surisa Kongthong; Kitlada Srichomthong; Rattaket Choeyklin

doi:10.1016/j.phytochem.2012.11.022

Lanostane triterpenes from cultures of the Basidiomycete Ganoderma orbiforme BCC 22324

Phytochemistry. 2013 Mar:87:133-9. doi: 10.1016/j.phytochem.2012.11.022. Epub 2012 Dec 29.

Authors

Masahiko Isaka¹, Panida Chinthanom, Surisa Kongthong, Kitlada Srichomthong, Rattaket Choeyklin

Affiliation

¹ National Center for Genetic Engineering and Biotechnology (BIOTEC), Klong Luang, Pathumthani 12120, Thailand. isaka@biotec.or.th

PMID: 23280041
DOI: 10.1016/j.phytochem.2012.11.022

Abstract

Seven lanostane triterpenoids, ganorbiformins A-G, together with twelve known compounds, were isolated from cultures of the mushroom fungus Ganoderma orbiforme BCC 22324. Ganorbiformin A is an unusual rearranged analog, whereas the other compounds share the same lanostane skeleton with known ganoderic acids. The C-3 epimer of ganoderic acid T also exhibited significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra (MIC 1.3 μM).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Basidiomycota / chemistry*
Microbial Sensitivity Tests
Molecular Structure
Triterpenes / chemistry*
Triterpenes / pharmacology

Substances

Antineoplastic Agents
Triterpenes