Here, we report the case of a 40-year-old woman who was discovered upon examination to have a lump in her left breast. Breast ultrasonography revealed a hypoechoic mass of size 2.5×2.5 cm, shaped irregularly with fine calcification in the left DE area. A needle biopsy was performed and the resulting pathological diagnosis was invasive cancer(apocrine carcinoma, T2N0M0, Stage IIA),negative for estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor type 2(HER2). Neoadjuvant chemotherapy was then performed with docetaxel/cyclophosphamide (TC)(4 courses) and epirubicin/cyclophosphamide (EC)(4 courses), after which ultrasonography revealed a significant reduction in mass, with a hypoechoic area of 1.0 cm×1.0 cm. Using magnetic resonance imaging (MRI), the tumor- contrast enhancement effect disappeared after the TC therapy, but the strong tumor-contrast enhancement enhancement effect diffused after EC therapy. Left breast segmentectomy and axillary lymphadenectomy were performed, and the tumor disappeared. The effectiveness of the chemotherapy was judged to be grade 3, and there was no subsequent metastasis or recurrence.