Abstract
A subunit vaccine, RBD-S, is under development to prevent severe acute respiratory syndrome (SARS) caused by SARS coronavirus (SARS-CoV), which is classified by the US NIH as a category C pathogen. This vaccine is comprised of a recombinant receptor-binding domain (RBD) of the SARS-CoV spike (S) protein and formulated on alum, together with a synthetic glucopyranosyl lipid A. The vaccine would induce neutralizing antibodies without causing Th2-type immunopathology. Vaccine development is being led by the nonprofit product development partnership; Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development in collaboration with two academic partners (the New York Blood Center and University of Texas Medical Branch); an industrial partner (Immune Design Corporation); and Walter Reed Army Institute of Research. A roadmap for the product development of the RBD-S SARS vaccine is outlined with a goal to manufacture the vaccine for clinical testing within the next 5 years.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adjuvants, Immunologic / administration & dosage
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Aluminum Compounds / administration & dosage
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Animals
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Antibodies, Neutralizing / immunology
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Antibodies, Viral / immunology
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Antigens, Viral / immunology*
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Clinical Trials as Topic
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Humans
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Lipid A / administration & dosage
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Membrane Glycoproteins / immunology*
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Phosphates / administration & dosage
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Protein Structure, Tertiary
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Severe Acute Respiratory Syndrome / immunology
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Severe Acute Respiratory Syndrome / prevention & control*
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Severe acute respiratory syndrome-related coronavirus / immunology*
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Severe acute respiratory syndrome-related coronavirus / pathogenicity
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Spike Glycoprotein, Coronavirus
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Vaccines, Subunit / immunology
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Vaccines, Synthetic / immunology
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Viral Envelope Proteins / immunology*
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Viral Vaccines / immunology*
Substances
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Adjuvants, Immunologic
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Aluminum Compounds
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Antibodies, Neutralizing
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Antibodies, Viral
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Antigens, Viral
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Lipid A
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Membrane Glycoproteins
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Phosphates
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Spike Glycoprotein, Coronavirus
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Vaccines, Subunit
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Vaccines, Synthetic
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Viral Envelope Proteins
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Viral Vaccines
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spike glycoprotein, SARS-CoV
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spike protein, mouse hepatitis virus
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aluminum phosphate