Biomimetic antireflective silicon nanocones array for small molecules analysis

J Am Soc Mass Spectrom. 2013 Jan;24(1):66-73. doi: 10.1007/s13361-012-0498-4. Epub 2012 Dec 19.

Abstract

Biomimetic antireflective silicon nanocones array is used for analysis of small molecules by mass spectrometry. The role of the absorbed laser energy and its distribution in the laser desorption/ionization process has been investigated by varying the antireflective features precisely. By optimizing the antireflective silicon array, the absorbed laser energy can be channeled completely into the desorption/ionization of analytes. The optimized silicon array exhibits excellent performance to detect peptide, amino acid, drug molecule, and carbohydrate without any interference in the low-mass region.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomimetic Materials / chemistry*
  • Bradykinin / analysis
  • Glucose / analysis
  • Glycosuria / urine
  • Humans
  • Models, Chemical
  • Nanostructures / chemistry*
  • Nanostructures / ultrastructure
  • Polyethylene Glycols / chemistry
  • Signal-To-Noise Ratio
  • Silicon / chemistry*
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation*
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods*

Substances

  • Polyethylene Glycols
  • Glucose
  • Bradykinin
  • Silicon