Shaping the p53 response with nucleoporins

Melanie L Yarbrough; Michael A White; Beatriz M A Fontoura

doi:10.1016/j.molcel.2012.11.027

Shaping the p53 response with nucleoporins

Mol Cell. 2012 Dec 14;48(5):665-6. doi: 10.1016/j.molcel.2012.11.027.

Authors

Melanie L Yarbrough¹, Michael A White, Beatriz M A Fontoura

Affiliation

¹ Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Abstract

In this issue, Singer et al. (2012) reveal that the nucleoporin Nup98 supports adaptation to genotoxic stress by protecting specific p53-induced mRNAs from exosome-dependent degradation, suggesting that wild-type Nup98 may possess tumor suppressor function.

Publication types

Comment
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Abstract

Publication types

Grants and funding