Abstract
Amyloidotic cardiomyopathy is still a widely underdiagnosed condition that usually requires endomyocardial biopsy (EMB) for a definite diagnosis. 99mTc-3,3-diphosphono-1,2-propanodicarboxylic acid (99mTc-DPD) has proven highly sensitive for detecting amyloidotic cardiomyopathy due to transthyretin-related amyloid deposition. Herein we report the first description of the (99mTc-DPD scintigraphy profile in a patient with suspected amyloidotic cardiomyopathy and a final EMB- and genetically-proven diagnosis of familial apolipoprotein AI amyloidosis due to Leu174Ser variant.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Amyloid Neuropathies, Familial / complications
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Amyloid Neuropathies, Familial / diagnosis
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Amyloid Neuropathies, Familial / diagnostic imaging
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Amyloid Neuropathies, Familial / metabolism*
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Apolipoprotein A-I / genetics*
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Cardiomyopathies / complications
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Cardiomyopathies / diagnosis
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Cardiomyopathies / diagnostic imaging
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Cardiomyopathies / metabolism*
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Diphosphonates / metabolism*
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Humans
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Male
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Middle Aged
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Mutation
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Myocardium / metabolism
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Myocardium / pathology
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Organotechnetium Compounds / metabolism*
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Radionuclide Imaging
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Radiopharmaceuticals / metabolism*
Substances
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Apolipoprotein A-I
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Diphosphonates
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Organotechnetium Compounds
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Radiopharmaceuticals
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technetium Tc 99m 1,1-diphosphonopropane-2,3-dicarboxylic acid
Supplementary concepts
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Amyloidosis, Hereditary, Transthyretin-Related