Background: Giant cell reparative granulomas (GCRGs) are rare lesions in the cranial bones. We present a case of this rare lesion emanating from the clivus and replacing the sphenoid sinus, a highly unusual location for this entity.
Case description: The case and clinical course of a 29-year-old female who presented with a large sphenoid mass are described here. The patient presented with symptoms of severe headache and diplopia; imaging demonstrated a large sphenoid mass which was completely resected via an endoscopic endonasal approach. It was based on the clivus and was shown to be a GCRG.
Conclusion: GCRGs are benign granulomatous lesions which should be considered in the differential in the setting of a sphenoid mass.
Keywords: Clivus; diplopia; giant cell reparative granuloma; giant cell tumor; neurofibromatosis-1.