Which way is forward in the treatment of rectal cancer?

Nat Rev Clin Oncol. 2013 Jan;10(1):12-3. doi: 10.1038/nrclinonc.2012.217. Epub 2012 Dec 11.

Abstract

Preoperative 5-fluorouracil-based chemoradiation with optimal surgery provides very effective local control in locally advanced rectal cancer. Does adding oxaliplatin as a radiosensitizer provide any additional benefit? Is more always better?

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Clinical Trials as Topic
  • Combined Modality Therapy
  • Fluorouracil / administration & dosage
  • Humans
  • Organoplatinum Compounds / administration & dosage
  • Oxaliplatin
  • Radiation-Sensitizing Agents / therapeutic use*
  • Radiotherapy Dosage
  • Rectal Neoplasms / therapy*

Substances

  • Organoplatinum Compounds
  • Radiation-Sensitizing Agents
  • Oxaliplatin
  • Fluorouracil