Reproducibility of linear array for human papillomavirus genotyping

J Clin Microbiol. 2013 Feb;51(2):625-8. doi: 10.1128/JCM.03036-12. Epub 2012 Nov 28.

Abstract

We conducted a Linear Array test/retest analysis using cytologic specimens from 198 women. A total of 67.2% of samples had the same human papillomavirus (HPV) types detected in both tests (type-specific positive agreement was 83.3% overall [Kappa = 0.9] and 86.8% for carcinogenic types [Kappa = 0.92]). Discordance was highest with a low hybridization signal strength. Overall, Linear Array was highly reproducible.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Female
  • Genotype*
  • Genotyping Techniques*
  • Humans
  • Papillomaviridae / classification*
  • Papillomaviridae / genetics*
  • Reproducibility of Results
  • Sensitivity and Specificity