PEI conjugated gold nanoparticles: efficient gene carriers with visible fluorescence

Adv Healthc Mater. 2012 May;1(3):337-41. doi: 10.1002/adhm.201200033. Epub 2012 Apr 2.

Abstract

Low molecular weight polyethyleneimines were conjugated onto gold nanoparticles to form Au-PEI conjugates. Au-PEI is the first reported gene carrier which has both high transfection efficiency and strong fluorescence. Au-PEI showed higher transfection efficiency and it can be used for bioimaging because it can be detected by confocal laser scanning microscopy and in vivo bioimaging system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CHO Cells
  • COS Cells
  • Chlorocebus aethiops
  • Cricetinae
  • Cricetulus
  • Fluorescent Dyes / chemistry*
  • Gold / chemistry*
  • HeLa Cells
  • Humans
  • Imines / chemistry*
  • Materials Testing
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Microscopy, Fluorescence / methods*
  • Nanocapsules / chemistry*
  • Nanocapsules / ultrastructure
  • Particle Size
  • Polyethylenes / chemistry*
  • Transfection / methods*

Substances

  • Fluorescent Dyes
  • Imines
  • Nanocapsules
  • Polyethylenes
  • poly(ethylene imine)
  • Gold