Double integration band of HTLV-1 in a young patient with infective dermatitis who developed an acute form of adult T-cell leukemia/lymphoma

Pedro D Oliveira; Marcelo Magalhães; Juliana M Argolo; Achiléa L Bittencourt; Lourdes Farre

doi:10.1016/j.jcv.2012.10.010

Double integration band of HTLV-1 in a young patient with infective dermatitis who developed an acute form of adult T-cell leukemia/lymphoma

J Clin Virol. 2013 Feb;56(2):163-6. doi: 10.1016/j.jcv.2012.10.010. Epub 2012 Nov 20.

Authors

Pedro D Oliveira¹, Marcelo Magalhães, Juliana M Argolo, Achiléa L Bittencourt, Lourdes Farre

Affiliation

¹ Service of Dermatology, Complexo Hospitalar Universitário Prof. Edgard Santos, Federal University of Bahia, Rua Dr. Augusto Viana, s/n, Canela, CEP: 40.110-060, Salvador, Bahia, Brazil.

PMID: 23182458
DOI: 10.1016/j.jcv.2012.10.010

Abstract

Few cases of acute adult T-cell leukemia/lymphoma (ATL) have been diagnosed in young patients. This report is the first to describe a young girl with infective dermatitis associated with HTLV-1 that progressed to acute ATL with Southern blot hybridization and gamma-TCR-rearrangement revealing a monoclonal pattern with two copies of the provirus.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Blotting, Southern
Dermatitis / complications
Dermatitis / pathology*
Dermatitis / virology*
Female
Gene Rearrangement
Genes, T-Cell Receptor gamma
Human T-lymphotropic virus 1 / genetics*
Human T-lymphotropic virus 1 / pathogenicity*
Humans
Leukemia-Lymphoma, Adult T-Cell / complications
Leukemia-Lymphoma, Adult T-Cell / pathology*
Leukemia-Lymphoma, Adult T-Cell / virology*
Proviruses / genetics
Virus Integration*
Young Adult