Retroviral danger from within: TLR7 is in control

Arun K Mankan; Veit Hornung

doi:10.1016/j.immuni.2012.10.009

Retroviral danger from within: TLR7 is in control

Immunity. 2012 Nov 16;37(5):763-6. doi: 10.1016/j.immuni.2012.10.009.

Authors

Arun K Mankan¹, Veit Hornung

Affiliation

¹ Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, Bonn, Germany.

PMID: 23159222
DOI: 10.1016/j.immuni.2012.10.009

Abstract

In this issue of Immunity, Yu et al. (2012) outline a fascinating model in which TLR7-mediated antibody production acts as a dominant immunosurveillance mechanism against endogenous retroviruses (ERVs), with additional support of TLR3 and TLR9 that function to prevent ERV-mediated malignancy.

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