M cell differentiation: distinct lineage or phenotypic transition? Salmonella provides answers

Hiroshi Ohno; Takashi Kanaya; Ifor R Williams

doi:10.1016/j.chom.2012.11.003

M cell differentiation: distinct lineage or phenotypic transition? Salmonella provides answers

Cell Host Microbe. 2012 Nov 15;12(5):607-9. doi: 10.1016/j.chom.2012.11.003.

Authors

Hiroshi Ohno¹, Takashi Kanaya, Ifor R Williams

Affiliation

¹ Laboratory for Epithelial Immunobiology, RIKEN Research Center for Allergy and Immunology, Kanagawa 230-0045, Japan. ohno@rcai.riken.jp

PMID: 23159049
DOI: 10.1016/j.chom.2012.11.003

Abstract

Whether M cells arise from a distinct lineage or result from phenotypic transition is a matter of debate. In this issue of Cell Host & Microbe, Tahoun et al. (2012) provide evidence that SopB, a virulence factor of Salmonella enterica serovar Typhimurium, can induce phenotypic transition of lymphoid follicle-associated enterocytes into M cells.

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