Abstract
Two proteins (21 and 48 kilodaltons) purified from endospore-spherule culture filtrates of Coccidioides immitis are identified as precipitin and complement-fixing antigens, respectively. To allow specific structural comparison to antigens identified by other investigators and as a first step to eventual serodiagnostic antigen production by recombinant DNA technology, amino-terminal amino acid sequences were determined for these antigens.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Amino Acid Sequence
-
Antigens, Fungal / isolation & purification*
-
Coccidioides / immunology*
-
Coccidioidomycosis / diagnosis
-
Coccidioidomycosis / immunology
-
Complement Fixation Tests
-
Fungal Proteins / immunology
-
Fungal Proteins / isolation & purification
-
Humans
-
Molecular Sequence Data
-
Molecular Weight
-
Precipitins / isolation & purification
-
Serologic Tests
Substances
-
Antigens, Fungal
-
Fungal Proteins
-
Precipitins