Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects

Diabetes Res Clin Pract. 2012 Dec;98(3):e23-7. doi: 10.1016/j.diabres.2012.09.044. Epub 2012 Oct 27.

Abstract

We tested the association of TCF7L2 variants with type 2 diabetes (T2DM) in 691 Lebanese people and 919 controls. rs7901695, rs4506565, rs7903146, rs12243326, rs7895340, and rs12255372 minor allele frequencies were higher in T2DM. Haplotype analysis (rs7901695-rs4506565-rs7903146-rs12243326-rs7895340-rs11196205-rs12255372) identified positively- (2122112, 2222222) and negatively- (1111111) T2DM-associated haplotypes. TCF7L2 is a common T2DM candidate gene in Lebanese people.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alleles
  • Arabs
  • Diabetes Mellitus, Type 2 / genetics*
  • Diabetes Mellitus, Type 2 / metabolism
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Haplotypes
  • Humans
  • Lebanon
  • Linkage Disequilibrium
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Transcription Factor 7-Like 2 Protein / genetics*
  • Transcription Factor 7-Like 2 Protein / metabolism

Substances

  • TCF7L2 protein, human
  • Transcription Factor 7-Like 2 Protein