Pubertal disorders and bone maturation

Endocrinol Metab Clin North Am. 2012 Dec;41(4):805-25. doi: 10.1016/j.ecl.2012.08.003.

Abstract

Bone age (BA) indicates more clearly than chronologic age how far an individual has progressed toward full maturity, and predicts the potential for further growth. Single or serial skeletal age estimations help to confirm the diagnosis of normal puberty and normal pubertal variants such as constitutional delay of growth and puberty, premature therlache, and precocious adrenarche. BA can aid in the clinical workup of children whose sexual maturation is early or delayed. Although BA is considered a qualitative rather than quantitative measure, it serves to round out the clinical picture, providing information without which diagnosis could not be achieved.

Publication types

  • Review

MeSH terms

  • Adolescent
  • Adolescent Development / physiology
  • Age Determination by Skeleton
  • Body Height / physiology
  • Bone Development / physiology
  • Child
  • Child Development / physiology
  • Epiphyses / diagnostic imaging
  • Epiphyses / physiology
  • Female
  • Gonadotropin-Releasing Hormone / agonists
  • Gonadotropin-Releasing Hormone / analogs & derivatives
  • Gonadotropin-Releasing Hormone / therapeutic use
  • Growth Disorders / drug therapy
  • Growth Disorders / etiology
  • Growth Hormone / therapeutic use
  • Humans
  • Male
  • Puberty / physiology*
  • Puberty, Delayed / complications
  • Puberty, Delayed / physiopathology*
  • Puberty, Precocious / complications
  • Puberty, Precocious / physiopathology*

Substances

  • Gonadotropin-Releasing Hormone
  • LHRH, Ala(6)-Gly(10)-ethylamide-
  • Growth Hormone